As a child she vanished from the Hidden Leaf Village as she discovered Danzo wa the one who took her father and brother that were missing finding them dump somewhere with their eyes missing stabbed and very violently mutilated. She took her families ancestor secret scrolls along with her. She was one out of numbers of missing Uchiha clan members.
Her mother died before massacre of broken heart when lost her husband, son and daughter in one year. In secret she actually helped her daughter runaway, she wanted to save her family even if it meant helping Orihime vanish without a trace to hope someone would keep the clan alive.
As she travel she trained by herself to become stronger to defend herself as she is female rogue ninja that travels. As she became also a beauty.