Regina is the only Brando who doesnโt have the Joestar birthmark, she ran from her father DIO while she was in her late teens, after finding out how cruel and heartless he was to others, she even blamed him for her motherโs death. After she turned 20, her father appeared on her doorstep to talk to her, why he has been killing the humans, he knew there were humans are much like his own father, Dario, so he tortured those people and killed them, for Reginaโs sake.
Her married life.
Regina had been married twice, however, her husbands were abominations, thus, getting rid of them herself so her children would be safe by using her charisma, a black Widow and puffer fish poison. Her first husband would murder children and animals for fun.Her second husband Vincent Agreste was abusive so she killed him but the time she was killing him, her son Gabriel was up that stormy night and saw his father was already dead from the puffer fish poison as the black widow was eating away his brain.
AU the death of Gabriel.
Once Gabriel was born, theres was no sound, which broke Regina's heart, she knew her son was dead, she set out to find a way to revive her son.